Rennes host Tottenham Hotspur at Roazhon Park on matchday one in Group G, which also consists of the likes of Vitesse and NS Mura.
The Ligue 1 outfit are currently 11th in the table, following an indifferent start to their league campaign, seeing them win one match against Nantes by a 1-0 scoreline, as well as drawing 1-1 with both Brest and Lens, before losing 2-0 in back-to-back matches against Angers and Reims.
To qualify for the Europa Conference League, Rennes beat Norwegian Elitserien side Rosenborg 5-1 on aggregate, with goals from Nayef Aguerd and Serhou Guirassy sealing the aggregate scoreline in a 2-0 home win.
Tottenham have started life well under Nuno Espirito Santo, although they did suffer a shock 3-0 loss to Crystal Palace on the weekend, meaning that they have managed nine points from three matches, following hard-earned 1-0 victories over Manchester City, Wolverhampton Wanderers and Watford.
Spurs beat Portuguese Primeira side Pacos de Ferreria to qualify for this tournament following their seventh-place finish in the Premier League last season. Spurs won their qualifying playoff against the Portuguese side 3-1 on aggregate, as they lost 1-0 away due to fielding a weakened team, before hammering Pacos 3-0 at the Tottenham Hotspur Stadium thanks to a brace from Harry Kane, as well as an own goal from Vitorino Antunes.
Prediction: Rennes 1 – 2 Tottenham Hotspur 8/1