This should be an even game between two sides desperate to win. Home advantage for Atlético is big, especially given Leverkusen's last two Champions League games away from home have seen them lose 4-0 to Liverpool and draw 1-1 with Brest. Whether that'll be enough for a win is a different matter, with the Germans arguably the superior side.
BTTS has occurred in three of Atlético's last four in the Champions League and three of Leverkusen's last four in the league, so we fancy both sides to find the back of the net in this one. In a game between two sides of similar quality, we think the spoils will be shared. Atlético Madrid 1-1 Bayer Leverkusen.