Ajax enter this game as firm favourites as they are in red-hot form, having won all of their last five matches, which included impressive wins over the likes of Galatasaray and Feyenoord.
The Amsterdam club come into the second leg as firm favourites, having deservedly beaten Union Saint-Gilloise 2-0 in the first leg. Ajax have a very strong home record, with their only defeats at the Johan Cruijff Arena across all competitions coming in the Second Qualifying Round to Panathinaikos and Lazio on matchday six of the Group Stage.
On top of this, Union Saint-Gilloise have struggled away from home in the Europa League, as they suffered defeats to the likes of Fenerbahçe, Midtjylland and Rangers - they have scored in three of their last four Europa League away days, so expect the Both Teams to Score market to land here.
Prediction: Ajax 2-1 Union Saint-Gilloise