Manchester United vs Lyon Prediction, Preview & Betting Tips

Manchester United versus Lyon will be an intriguing contest in the Europa League.

The Red Devils will feel as though they should’ve won the first leg, as both Lyon goals in that 2-2 draw came as a result of two goalkeeper errors from Andre Onana.

United are the only unbeaten side left in the UEFA Europa League as they have won six times and drawn five, with four of those victories coming at home against the likes of PAOK (2-0), Bodo/Glimt (3-2), Rangers (3-2) and Real Sociedad (4-1).

The Both Teams to Score market has landed in both of Manchester United’s last two matches, as well as in all of Lyon’s last five games, hence why we are predicting United to win with Both Teams to Score.

Prediction: Manchester United 2-1 Lyon

Manchester United hosts Lyon at Old Trafford in the second leg of their Europa League quarter-final, with this being a do-or-die fixture for the Red Devils season.

Date: 17/04/2025

Location: Old Trafford

Time: 8pm

The first leg of this tie resulted in a 2-2 draw as Ryan Cherki scored a 95th-minute equaliser for Lyon after goals from Leny Yoro and Joshua Zirkzee had given the Red Devils a 2-1 lead after initially conceding to a Thiago Almada free kick.

Ruben Amorim will know that Manchester United’s season solely relies on winning this competition, as the Old Trafford club are having a dismal league campaign, as they sit 14th in the Premier League standings with just 38 points from 32 matches, having won ten, drawn eight and lost 14.

The Europa League has provided some good escapism for the Red Devils, as they managed to finish third in the Group Stage with 18 points from eight matches, while in the knockout stages, United managed to advance past Real Sociedad via an emphatic 5-2 aggregate scoreline.

Lyon are in contention to qualify for next season’s Champions League via Ligue 1, as they are fourth in the table with 51 points from 29 matches, seeing them sit just two points behind second-place AS Monaco.

Les Gones also had a solid Group Stage performance in the Europa League, as they accumulated 15 matches from eight matches, while in the Round of 16, they thrashed FCSB via a 7-1 aggregate scoreline.

Manchester United versus Lyon will be shown live on TNT Sports 1 and TNT Sports Ultimate.

Manchester United

Jonny Evans, Matthijs de Ligt, Lisandro Martínez, Toby Collyer, Amad Diallo and Joshua Zirkzee will all miss this clash due to injury.

Lyon

Malick Fofana and Ernest Nuamah will both miss Lyon’s trip to Manchester on Thursday, having suffered knee injuries.

Manchester United

Manchester United are without a win in their last four matches since beating Leicester City 3-0 on 16th March, where Rasmus Hojlund, Alejandro Garnacho and Bruno Fernandes all got on the scoresheet.

Since then, the Red Devils have suffered defeats to Nottingham Forest (1-0) and Newcastle United (4-1) on either side of a 0-0 stalemate with Manchester City and their 2-2 draw with Lyon last week.

Lyon

Lyon earned a crucial 3-1 win over Auxerre at the weekend thanks to goals by Georges Mikautadze, Rayan Cherki and Alexandre Lacazette.

In the run-up to that match, Lyon had drawn with Manchester United (2-2) after beating Lille (2-1) and Le Havre (4-2) on either side of a 4-2 loss at Strasbourg.

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