Real Sociedad come into this game as firm favourites due to quality of their squad, as well as the fact that they have been strong at home in the Europa League, having won all of their last three matches at Reale Arena having beaten the likes of Ajax, Dynamo Kyiv and PAOK.
The Spaniards managed to win the away leg despite resting the likes of Mikel Oyarzabal, Martin Zubimendi, Sergio Gomez, Nayef Aguerd, Luka Sucic and more.
Midtjylland have won just one of their last six games in Europe, with their sole victory coming away at Ludogorets on matchday seven.
Prediction: Real Sociedad 2-0 Midtjylland