Roma's home form has been excellent of late, with the Serie A side unbeaten in their last eight games in Rome, winning seven of those. Porto, meanwhile, have struggled on the road in this competition, winning just one of their last five, and two of their last ten, away games in the Europa League.
Based on that, and the fact that Roma got the more favourable result away from home, we think they'll come out on top here. Roma 2-1 Porto.