Barcelona are undoubtedly favourites for this fixture, as the title challengers should overcome Rayo Vallecano, despite the visitors' tremendous success in chasing European football this season.
Barcelona are in excellent form under Hansi Flick, as his style of play has clearly made an imprint on the club. Los Cules are the top scorers of the division, with 64 goals scored in 23 matches and the home side are unbeaten in their last 11 games in all competitions.
Despite the advantage for Barcelona, Rayo Vallecano could cause Barcelona some problems if the home side have a bad performance - with the visitors in sixth place in the league, chasing a potential European spot.
The visitors are unbeaten in their last four matches but are also without a clean sheet in the previous four meetings between the two teams.
We predict Barcelona will beat Rayo Vallecano in a comfortable home win.
Barcelona 3-0 Rayo Vallecano