The Europa League heavyweights Sevilla will head on the road to the Netherlands where PSV Eindhoven are aiming to overturn a 3-0 deficit in the playoffs as the La Liga side eased to a win this time last week on home soil.
Sevilla's turnaround in form has been excellent in the past few gamweeks. The club were fighting relegation and even in the bottom three just before the break for the World Cup, and the La Liga outfit have since responded with yet another Europa League win and a fantastic rise up into 12th in La Liga.
Youssef En-Nesyri scored in the 3-0 win against PSV last week to kick things off in the first half, as Lucas Ocampos scored early on in the second 45, just before a goal from Nemanja Gudelj.
Sevilla went on to draw with Rayo Vallecano soon after in a 1-1 draw. After also beating Mallorca 2-0, the club now head into this one with a three-game unbeaten run since losing 3-0 at the Camp Nou to Barcelona.
On the other hand, despite the improved form from Jorge Sampaoli's side, his men are still sat in sixth in the table and head into the game with just 24 goals scored and 30 conceded.
As for PSV, they are down into fourth after a 2-2 draw with Utrecht. Luuk de Jong scored that day, as Johan Bakayoko scored netted for the club. Not long before this, however, the club smashed Groningen 6-0 at home and beat Emmen in the round of 16 of the KNVB Cup, but in reality, the 3-0 loss in Seville has now left a sour taste this month.
An early goal could change everything and Sevilla will likely make changes. At 1/50, however, Sevilla should stroll past PSV and make it into the next round once again in the Europa League.