Chelsea are in very good shape heading into this one and it's hard to see them coming up short. Chelsea have scored 17 goals in their last five games, making them a ruthless attacking unit.
The Blues have lost only once this season in a game that was effectively a dead rubber at the time - a 2-1 defeat against Servette in a second leg tie.
Both teams to score has occurred in all of Chelsea's last three games so we expect that trend to continue here.
Ultimately, Panathinaikos are likely not in good enough form to take advantage of Chelsea's rotations, so the Blues should continue their fine form. Panathinaikos 1-3 Chelsea.