Expect Manchester United to be the favourites for this one despite their mixed form under Ruben Amorim. United are unbeaten in the Europa League this season, with three draws and two consecutive wins to place the Red Devils in a brilliant position to potentially move into the top eight.
Plzen have the same record as Manchester United in this competition. However, the standard of opposition is significantly weaker - with United facing the likes of Porto and Fenerbahce and Plzen facing the likes of Ludogrets and Dynamo Kyiv. Manchester United will most likely win this one, as Amorim's men have four wins in their previous seven – Viktoria Plzen 0-2 Man United