Despite their poor league form, Southampton comfortably dispatched Swansea in the previous round, and although Burnley are a superior side, they're still largely unimpressive in what is a fairly weak year in the Championship.
Burnley have failed to score in three of their last four games and regularly have difficulties in front of goal, so they'll find it hard to get on the scoresheet here. Southampton still have enough quality to give the top Championship teams a very rough ride, and we think they'll do that here. Southampton 2-0 Burnley.