Manchester United will travel to Rome for the first time in just over a decade to face a struggling Roma side who have conceded 11 goals in their last three games.
After losing 3-2 to Cagliari and 6-2 to United, Roma's woes worsened after losing 2-0 to Sampdoria, which has now all but confirmed their absence from European football next campaign, as they remain seventh in the league.
As a result of this torrid form, the Italian outfit have announced that manager Paulo Fonseca will depart at the end of the season and be replaced by former United manager Jose Mourinho, which could force Fonseca to go all out in this game.
However, it will take nothing short of a miracle for Roma to advance in this one, given United's dominant display at Old Trafford which saw them come from 2-1 down to win the game 6-2, with each goal absolutely delightful.
Bruno Fernandes was in tip-top form once again that day, and whilst he may miss out, it's believed that Ole Gunnar Solskjaer won't make too many changes after the club's clash with Liverpool was postponed due to fan protests at Old Trafford. As a result, United have had a week to rest their players, but in truth, given how they will now have a midweek game each week before the season's conclusion.
Ultimately, it seems as if the team news will be what decides this clash, as United could rest too many and allow Roma to win on the night. Although, the four-goal haul should be too much and the Red Devils should get back into the Europa League final for the first team since they won the competition in 2017.
We're going for Roma to win it on the night as a result of United's changes, but the away side will advance.