Thomas Tuchel's men are attempting to bring an end to Spain's excellent unbeaten run as they travel to Madrid to take on the world champions on Sunday.
Both sides have booked their place in the Nations League quarter-finals in March, so this weekend will determine who takes top spot.
Spain are top of the group on 15 points, while England lag behind on 12. When these two sides met at Wembley in late September, Spain ran out 3-2 winners. England did, though, put in a solid performance, with individual errors ultimately proving their undoing.
Manager Tuchel has spoken openly about the opportunity for the team to lay down a marker here, and toppling Spain in their own back yard would be just that.
The Three Lions are riddled with defensive injuries, however, so winning in Madrid is going to be a huge uphill battle.
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