United are missing a few key players so this one won't be straightforward, but they've got plenty enough quality to come out on top.
Alejandro Garnacho and Bruno Fernandes registered 3.51 and 2.6 shots per 90 minutes last season and could fill their boots here, while Fernandes picked up 9 bookings last season and could be a solid bet for a booking.
Despite the addition of Emile Smith-Rowe, Fulham still look slightly weaker than they did last season on the whole following the departures of Tosin Adarabioyo and João Palinha so this game may have come slightly too soon in the calendar for them.
United have won four of their last five head-to-head meetings with Fulham and should kick off their Premier League campaign with three points. Man Utd 2-1 Fulham.