In a similar fashion to last season with Aymeric Laporte and Manchester City, the champions of England are set to defend their title without their main man at the back, as Liverpool's Virgil van Dijk is set to undergo knee surgery.
The talismanic defender has powered the Reds to the Champions League and Premier League within the past two years, but for the first time in three seasons, Liverpool's main man will no be present.
We take a look at the Premier League winner odds, top four odds and how this affects other clubs and Liverpool after van Dijk's terribly unfortunate injury.
And there are no two ways about it: the title race is now wide open.