Manchester City come into this match as obvious favourites against a Leyton Orient side that sit sixth-place in League One.
Pep Guardiola’s men will be going all out to try and win the likes of the FA Cup following a below-par league campaign to date, so expect there to be no shock here at Brisbane Road, especially when considering that City showed absolutely no mercy when they thrashed Salford City 8-0 in the Third Round.
Leyton Orient have a decent defensive record for a League One side, as they’ve conceded just 25 times in 28 matches, however, City are the third top scorers in the Premier League with 48 in 24 games and will be determined to put things right after their humiliating defeat to Arsenal on Sunday.
Prediction: Leyton Orient 0-4 Manchester City