United are coming into this game off the back of a pair of impressive performances, despite neither game resulting in a win. Southampton's most recent Premier League game was a 0-5 drubbing at the hands of Brentford, and the Saints are winless away from home this season, so it's hard to see them getting anything at Old Trafford, or even offering up much resistance.
The mood around Manchester United is rapidly improving, so this game feels well-timed for them to deliver a commanding win, and given four of their last five home games have seen over 2.5 goals, we think this one should be a relatively high-scoring encounter. Manchester United 3-0 Southampton.