For many years, England’s defence has been questioned and criticised for not being good enough to compete in major competitions, particularly since the likes of Rio Ferdinand and John Terry retired from international football, without any reliable replacements for them.
This tournament could, therefore, be an opportunity for young centre-backs to make themselves an England regular. With this said, however, the Sky Bet favourite to go to Euro 2021 is understandably the United captain, Harry Maguire at 1/50.
Outside odds worth considering, although, are the likes of Japhet Tanganga at 5/1, Fikayo Tomori at 5/4 and Mason Holgate 3/1, considering all are making significant impacts at their club.
Tomori has exploded onto the scene this season with his modern defensive style, becoming a first-team player for Frank Lampard’s Chelsea, giving Southgate a significant reason to select the young centre half for his side in a year's time.
Spurs youngster, Tanganga, is also an outsider to consider, as he has played a role in Spurs' back three – a formation some believe Southgate could employ for the Euro’s, making the odds of 5/1 hard to ignore, considering the youngster's performances already.
Right-back Kyle Walker was an England regular for many seasons but has found his way out the squad entirely since the rise of players like Trent Alexander-Arnold and Kieran Trippier.
Interestingly, Walker's odds are priced at 5/2, and although perhaps not the player he once was, he will still be in with a shout, especially considering his versatility in moving to centre-back under Southgate.
On the other hand, Aaron Wan-Bissaka has had an incredible season with United making the most tackles in the Premier League thus far. Many out there have argued his defensive brilliance should give him the nod over Alexander-Arnold in the starting XI, which makes the United star's 6/4 price to be included in the squad very appealing.
Elsewhere, 2018 World Cup hero, Trippier, is also worth considering at 2/1, as is the vastly improved Luke Shaw at 6/5. Also, Tyrone Mings is priced at 7/4 and should Aston Villa still be in the Premier League in the summer of 2021, even he is worth a punt.
Bettors should also consider taking a look at Chris Smalling who's resurgence this year at Roma has had everyone talking - the United loanee is an eye-catching 4/1, despite his form.