Newcastle have a few absences to contend with but that's not something they're unfamiliar with after spending most of last season with a half-available squad. Ultimately, there's still a lot of quality in this team and they're likely going to be one of the better sides in the league this season, whereas Southampton could find life in this division pretty tough.
Alexander Isak has been on fire in preseason and after scoring 21 league goals last season it feels likely we're going to see his name on the scoresheet a lot, quite possibly starting this weekend.
Another man who's been on good form in preseason is Jacob Murphy, who managed 2.27 shots per 90 minutes last season and could be a good bet to open his account for the season here.
This is a very hard opening game of the campaign for the Saints and could be a sobering introduction to life back in the Premier League. Newcastle 3-1 Southampton.